(Funded by the Department of Health and Human Services and others number, NCT04338360.) IntroductionĬonvalescent Plasma Antibody Levels and Covid-19 Mortality ConclusionsĪmong patients hospitalized with Covid-19 who were not receiving mechanical ventilation, transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels was associated with a lower risk of death than transfusion of plasma with lower antibody levels. A lower risk of death within 30 days in the high-titer group than in the low-titer group was observed among patients who had not received mechanical ventilation before transfusion (relative risk, 0.66 95% confidence interval, 0.48 to 0.91), and no effect on the risk of death was observed among patients who had received mechanical ventilation (relative risk, 1.02 95% CI, 0.78 to 1.32).
The association of anti–SARS-CoV-2 antibody levels with the risk of death from Covid-19 was moderated by mechanical ventilation status. Of the 3082 patients included in this analysis, death within 30 days after plasma transfusion occurred in 115 of 515 patients (22.3%) in the high-titer group, 549 of 2006 patients (27.4%) in the medium-titer group, and 166 of 561 patients (29.6%) in the low-titer group. Patients who were enrolled through July 4, 2020, and for whom data on anti–SARS-CoV-2 antibody levels in plasma transfusions and on 30-day mortality were available were included in the analysis. The primary outcome was death within 30 days after plasma transfusion. national registry, we determined the anti–SARS-CoV-2 IgG antibody levels in convalescent plasma used to treat hospitalized adults with Covid-19.
Whether convalescent plasma with high antibody levels rather than low antibody levels is associated with a lower risk of death is unknown. Original Article Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19 List of authors.Ĭonvalescent plasma has been widely used to treat coronavirus disease 2019 (Covid-19) under the presumption that such plasma contains potentially therapeutic antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be passively transferred to the plasma recipient. The most trusted, influential source of new medical knowledge and clinical best practices in the world.Įditor’s Note: This article was published on January 13, 2021, at.
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